Episodes
Inside America’s AI Strategy: Infrastructure, Regulation, and Global Competition
All-In Podcast
1/22/2026
In a discussion moderated by Maria Bartiromo, David Sacks and Michael Kratsios analyze America's strategy in the global AI Race, primarily against China. David Sacks expresses confidence in the United States's position, citing the innovation from American Companies in Silicon Valley, which operates on a principle of Permissionless Innovation. However, both speakers highlight significant challenges, including the massive AI Infrastructure Buildout required for Data Centers and the associated Energy Challenges, which has turned the AI Race into a 'power race'. A key domestic issue is AI Regulation, with a debate between a chaotic Patchwork of state regulations and a proposed lightweight Federal AI Regulation. President Trump's administration is credited with setting a pro-innovation AI Action Plan and pushing back against what David Sacks calls Woke AI—politically biased models influenced by DEI principles, as seen in the rescinded Biden Executive Order on AI and exemplified by Google's Gemini controversy. The global US vs China AI Competition is fierce across the stack, from Chips (where the US leads) to AI Models. China holds advantages in energy production and public AI Optimism, and is promoting national champions like Huawei while blocking competitors like Nvidia. The US response includes the American AI Export Program to increase global Market Share of its technology. Michael Kratsios emphasizes the transformative potential of AI for
Satya Nadella on AI’s Business Revolution: What Happens to SaaS, OpenAI, and Microsoft?
All-In Podcast
1/21/2026
In an impromptu fireside chat at Davos, Jason Calacanis and David Sacks host Microsoft CEO Satya Nadella to discuss the business revolution driven by artificial intelligence. Nadella outlines his vision for the evolution of AI copilots and agents, moving beyond simple chat to autonomous agents that act as 'infinite minds' for knowledge workers. He explains how Microsoft has achieved significant revenue and profit growth with a flat headcount by embracing Organizational Change in Knowledge Work, using its subsidiary LinkedIn as an example of combining roles to increase velocity, a trend also seen at Alphabet and Meta. The conversation highlights the intense AI competition from companies like Elon Musk's xAI, Google, OpenAI, and Anthropic. Nadella emphasizes a Platform strategy, referencing ideas from Bill Gates and Peter Thiel, focused on the global Diffusion of technology for the American tech stack. He believes success is measured not just by market share but by the economic value created by the surrounding ecosystem, citing historical partnerships with Intel and SAP. Discussing the controversial OpenAI deal with Sam Altman, Nadella explains Microsoft's AI stack, which includes building 'token factories' on Azure and an app server. He predicts the LLM commoditization, comparing Foundation Models like LLMs to the database market, and expresses bullishness on a future with a mix of proprietary and Open-source AI models. Nadella is also committed
Iran's Breaking Point, Trump's Greenland Acquisition, and Solving Energy Costs
All-In Podcast
1/16/2026
The All-In Podcast hosts, Jason Calacanis, David Sacks, Chamath Palihapitiya, and David Friedberg, kick off by announcing their participation at Davos, where they will host interviews at the USA House, an event also featuring a talk by Donald Trump. The discussion pivots to geopolitics, with David Friedberg analyzing the Anti-regime protests in Iran against Ali Khamenei's regime. This situation is framed as a modern example of Information warfare, with technologies like Starlink countering state censorship, while the crisis is exacerbated by economic Sanctions on Iran from the United States. On the domestic front, the hosts discuss Microsoft's recent decision, influenced by public pressure from Donald Trump, for President Brad Smith to announce that their AI Data Centers will pay for their full energy and grid upgrade costs. This leads to a broader conversation about energy solutions, with Chamath Palihapitiya proposing that hyperscalers fund residential Solar and storage systems. In the AI hardware sector, a major development is OpenAI, led by CEO Sam Altman, striking a $10B deal with Cerebras, a company founded by Andrew Feldman that competes with firms like Grock, for their specialized AI Inference chips. A significant portion of the episode is dedicated to the proposed California Wealth Tax. The hosts, particularly David Sacks, vehemently oppose the measure, labeling it an Asset seizure tax that threatens Private property rights. The initiative is back
Supercharging A New FDA: Marty Makary on Science, Power & Patients
All-In Podcast
1/15/2026
In an extensive interview with David Friedberg, FDA Commissioner Marty Makary details the ambitious agenda of FDA Reforms under the Donald Trump Administration. A core focus is accelerating the Drug Approval Process to shorten Clinical Trial Timelines and enhance the United States' competitiveness in the US-China Biotech Competition. Key strategies include reducing the default for Pivotal Trials from two to one, replacing animal studies with Computational Modeling and Organ on a chip technology, and adopting Bayesian Statistics for real-time data analysis. Makary envisions a future of Continuous Trials and is enhancing Post-market Surveillance with AI. He also reaffirms his strong support for the Right to Try law. The reforms extend to public health guidance. Makary criticizes the field of Nutrition Science for creating a 'failed' Food Pyramid and shifts the focus from fats to the dangers of Refined Carbohydrates, which he links to the Obesity Epidemic and widespread Insulin Resistance. The rise of GLP-1s is discussed as a therapeutic response. In another move to rebuild public trust, the administration has revised the national Vaccine Schedule, creating a prioritized list of Core Essential Vaccines that stands apart from broader CDC recommendations. Lowering Drug Prices is a top priority for President Donald Trump. Makary outlines a multi-pronged strategy including Most Favored Nation Status Pricing, accelerating the approval of Biosimilars to create co
Why AI will dwarf every tech revolution before it: robots, manufacturing, AR glasses from CES 2026
All-In Podcast
1/14/2026
At a vibrant CES 2026 panel hosted by Jason Calacanis, Bob Sternfels of McKinsey and Hemant Taneja of General Catalyst declared that the ongoing AI Transformation will dwarf all prior tech revolutions. They highlighted the unprecedented Pace of Innovation since the launch of ChatGPT, which has led to a significant Value Creation Compression in the startup world. Taneja used his firm's investment in Anthropic as a prime example, contrasting its explosive growth against competitor OpenAI and the longer trajectory of past successes like Stripe. This new reality has spurred a novel Venture Capital Strategy at General Catalyst, which now acquires incumbent businesses—such as a health system in Ohio—to create real-world testbeds for its portfolio companies, accelerating Incumbent Transformation. From the corporate perspective, Sternfels detailed the challenges of Enterprise AI Adoption, particularly the internal CFO vs CIO Dilemma where leaders are torn between proving ROI and the existential threat of being disrupted. He revealed that McKinsey is navigating its own Workforce Transformation by deploying AI Agents at scale, aiming for a one-to-one ratio with human employees. This shift is causing a severe Job Market Disruption, exposing a Broken Education System ill-equipped for the future. The panel advocated for a new paradigm of Lifelong Learning that prioritizes uniquely human skills such as Creativity, Leadership, and Resilience. The discussion then pivoted to Phy
Adam Carolla on California’s Collapse: Fires, Failed Leadership, and Gyno-Fascism
All-In Podcast
1/12/2026
In an interview on the All-In Podcast with David Friedberg, comedian Adam Carolla discusses the collapse of California, using the one-year anniversary of the Palisades Fire and the failed Rebuilding Efforts in Los Angeles and Malibu as a prime example. He attributes the state's problems to failed leadership from figures like Mayor Karen Bass and Governor Gavin Newsom, and a culture of 'Gyno-fascism'—an excessive Safety Culture driven by women in power that prioritizes process over results, leading to crippling Red Tape from bodies like the Coastal Commission. He uses the societal response to COVID as a key example of this damaging culture in action. Carolla also critiques the rise of DEI ideology, which he argues has destroyed Meritocracy in industries like Hollywood, citing Kamala Harris as a 'DEI hire'. He further laments pervasive Media bias from outlets like the LA Times and New York Times. Carolla predicts a national self-segregation into 'Two Americas', metaphorically described as failing 'Safe spaces and octagons', with people fleeing to states like Florida and Texas. He also touches on how the political class will likely target Big Tech and AI as the next 'boogeyman' leading up to the 2028 Election. He endorses business-minded outsiders like Rick Caruso, Larry Elder, or Steve Hilton to fix the state. The discussion also covers the rise of Socialism, the Hard times make strong men (adage), and the concept of 'Luxury beliefs', wit
All-In's 2026 Predictions
All-In Podcast
1/9/2026
In their 2026 predictions episode, the All-In Podcast hosts, Jason Calacanis, Chamath Palihapitiya, David Friedberg, and David Sacks, cover a wide range of political, business, and technological forecasts. The discussion kicks off with David Sacks's recent move to Austin, Texas, framing a broader conversation about the controversial California Wealth Tax which is causing a capital flight from California, with notable figures like Larry Page and Sergey Brin of Google reportedly leaving. This tax proposal, promoted by figures like Ro Khanna and the SEIU, includes a punitive Super Voting Stock provision, prompting concern from Governor Gavin Newsom's administration. Politically, winners are predicted to be the Democratic Socialists of America (DSA) and politicians like Zohran Mamdani, while losers include Democratic Centrism and the Tech Industry, which is expected to become a populist target over issues like Censorship. A potential Trump Boom under Donald Trump is forecast, with predictions of 5-6% GDP Growth and a resurgent IPO market. Foreign policy may see the Monroe Doctrine replaced by a new Trump doctrine, rejecting Neocon Regime Change, and a potential Russia-Ukraine War Settlement is anticipated. In business, big winners are forecast to be Huawei, the prediction market platform Poly Market, the raw material Copper, and Amazon through its aggressive use of Robots. Conversely, the Software industrial complex is expected to be a major lo
Howard Lutnick: How America Can Hit 6% GDP Growth in 2026
All-In Podcast
1/8/2026
In an interview on the All-In Podcast with Chamath Palihapitiya, US Secretary of Commerce Howard Lutnick provides a detailed overview of the economic strategy of the Trump Administration, which he predicts could achieve 5-6% GDP Growth by 2026. The central pillar of this strategy is the strategic use of country-specific Tariffs to correct the long-standing US Trade Deficit, a policy driven by Donald Trump's view that the United States of America was being 'ripped off'. Lutnick highlights the innovative US-Japan Trade Deal, where Japan agreed to a $550 billion investment fund in exchange for tariff adjustments. This proactive stance is contrasted with China's economic strategy of state-subsidized dumping. The administration employs a Staircase Deal Model for negotiations, rewarding early partners like the UK with the best terms, which caused India under Modi to miss its chance. Similar successful deals were made with Korea and Europe. The administration is also focused on Reshoring Manufacturing for critical technologies. Lutnick details a revamp of the CHIPS Act, transforming it from a grant program into a tool of leverage. For instance, contractual DEI (Diversity, Equity, and Inclusion) requirements were used to compel TSMC to increase its investment in Arizona from $60 billion to over $165 billion. For Intel, the government took an equity stake instead of providing a simple handout. The Department of Commerce also oversees complex Export controls through its Bureau o
Massive Somali Fraud in Minnesota with Nick Shirley, California Asset Seizure, $20B Groq-Nvidia Deal
All-In Podcast
12/31/2025
The All-In Podcast features an extensive interview with 23-year-old investigative journalist Nick Shirley, who discusses his viral YouTube report on the massive Minnesota Daycare Fraud. This multi-billion dollar Entitlement Fraud involves exploiting the CCAP (Minnesota Child Care Assistance Program) and is linked heavily to the Somali community in Minnesota. The conversation explores the possibility that this is not just isolated crime, but part of a systemic Patronage System involving Political Corruption, where politicians like Minnesota Governor Tim Walz and the Minnesota State Government allegedly turn a blind eye in exchange for votes. The most explosive allegation is the potential for Terrorism Funding, with funds possibly being funneled to the terrorist group al-Shabaab. The discussion then broadens to a critique of widespread Government Waste in the US, citing California as another major example with its Homeless Industrial Complex. This leads to an analysis of the proposed California Billionaire Tax Act, which the hosts condemn as a form of Asset Seizure that threatens Private Property Rights. They argue that such populist measures gain traction due to failures like the lack of Universal Healthcare. The hosts believe these revelations vindicate figures like Elon Musk, who have long warned of such fraud, and predict that the Bond Market will eventually force a reckoning upon fiscally irresponsible states like California. In the final segment, Chamath Palihapitiya celebrates a vic